Anti-Phospho-STAT6 (Tyr641)(S57-365R)

Anti-Phospho-STAT6 (Tyr641)(S57-365R)

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Description :Rabbit Polyclonal Antibody

Species :

Tag :

Expression System:

Sequence :

Specificity :Recognizes the human STAT6 protein phosphorylated at Tyrosine 641

Cited Applications :ELISA, WB
Ideal working dilutions for each application should be empirically determined by the investigator.

Cross Reactivity :Human

Host Isotype / Clone# :Rabbit, IgG

Immunogen :The antibody was produced against synthesized peptide corresponding to residues surrounding Tyr641 of human STAT6 protein

Purification :Immunoaffinity chromatography

Stability :1yr at –20oC from date of shipment.

Sample Data :Western Blot of Anti-Phospho-STAT6 (Tyr641) (1:1,000) dilution. Lane 1: unstimulated Hela cell lysate. Lane 2: IL-4 stimulated Hela cell lysate. Load: 10 µg per lane.

Sample Data :Immunohistochemical analysis of human breast carcinoma pH9 tissue (left) with negative control (right) using Anti-Phospho-STAT6 (Tyr641).

Scientific Background :The STAT6 protein is a member of the STAT family of transcription factors that are activated by cytokines and phosphorylated by the receptor associated kinases. STATs form homo- or hetero-dimers that translocate to the cell nucleus where they act as transcription activators (1). STAT6 plays a central role in exerting IL4 mediated biological responses. STAT6 induces the expression of BCL2L1/BCL-XL, which is responsible for the anti-apoptotic activity of IL4. STAT6 mRNA has been detected in various tissues including peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung and placenta. STAT6 is critically involved in Th2 immune response (2).

References :
1. Weidinger, S. et al: Association of a STAT 6 haplotype with elevated serum IgE levels in a population based cohort of white adults. J. Med. Genet. 41: 658-663, 2004.

2. Wang, W. et al: The susceptibility to experimental myasthenia gravis of STAT6-/- and STAT4-/- BALB/c mice suggests a pathogenic role of Th1 cells. J. Immun. 172: 97-103, 2004.

Product Sheets (By Lot #) :

B3216-84.pdf

Research Areas :Apoptosis/Autophagy, Cancer, ERK/MAPK Pathway, Inflammation, JAK/STAT Pathway