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Anti-phospho-STAT5A (Ser780)(S56-365R)

Anti-phospho-STAT5A (Ser780)(S56-365R)

  • $325.00


Description :Rabbit Polyclonal Antibody

Species :

Tag :

Expression System:

Sequence :

Specificity :Recognizes the MEK1/2 protein phosphorylated at serine 780

Cited Applications :WB, IHC

Cross Reactivity :Human, Mouse and Rat

Host / Isotype / Clone# :Rabbit, IgG

Immunogen :Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser780

Purification :Affinity chromatography

Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Sample Data :Western blot analysis of extracts from HeLa cells using anti-phospho-STAT5A (Ser780) antibody.

Sample Data :Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-phospho-STAT5A (Ser780) antibody.

Scientific Background :Signal transducers and activators of transcription (STAT)5A is phosphorylated by receptor associated protein kinases in response to cytokines and growth factors (1). STAT proteins are responsible for the differentiation of helper T cells, thus playing key roles in regulating immune functions. In BCR-ABL-positive cells, STAT5 is constitutively activated by tyrosine phosphorylation. STAT5 activation results in upregulation of Bcl-XL and results in increased resistance to apoptosis. STAT5 is involved in expression and growth hormone-mediated sexually dimorphic regulation of cytochrome P450 3A10/lithocholic acid 6 beta-hydroxylase (2). STAT5A is phosphorylated at Ser780 in response to IL-2 stimulation (3).

References :
1. Wang, D. et al: Naturally occurring dominant negative variants of Stat5. Molec. Cell Biol. 16: 6141-6148, 1996.

2. A Subramanian et al: STAT 5 and NF-Y are involved in expression and growth hormone-mediated sexually dimorphic regulation of cytochrome P450 3A10/lithocholic acid 6beta-hydroxylase. Nucleic Acids Res. 1998; 26(9): 2173–2178.

3. Xue H H. et al: Serine phosphorylation of Stat5 proteins in lymphocytes stimulated with IL-2. Int Immunol. 2002 Nov;14(11):1263-71.

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Research Areas :Apoptosis/Autophagy, Cancer, ERK/MAPK Pathway, Inflammation, JAK/STAT Pathway, Cancer, Inflammation, ERK/MAPK Pathway, JAK/STAT Pathway, Apoptosis/Autophagy