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Anti-Phospho-STAT2 (Tyr690)(S53-365R)

Anti-Phospho-STAT2 (Tyr690)(S53-365R)

  • $369.00


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Description :Rabbit Polyclonal Antibody

Species :

Tag :

Expression System:

Sequence :

Specificity  :Recognizes the human STAT2 protein phosphorylated at Tyrosine 690

Cited Applications :ELISA, WB
Ideal working dilutions for each application should be empirically determined by the investigator.

Cross Reactivity :Human, Chimpanzee, Macaque, Vervet Monkey, Rat, Dog, Pig, Horse, Mouse and Bovine

Host Isotype / Clone# :Rabbit, IgG

Immunogen :The antibody was produced against synthesized peptide corresponding to a region near the N-Terminus of human STAT2 protein.

Purification :Affinity chromatography

Stability :1yr at –20oC from date of shipment.

Sample Data :Western blot using Anti-Phospho-STAT2 (Tyr690) antibody (1:1,000 dilution) shows detection of Stat2pY690 protein (arrowhead) in Jurkat cells without (left lane) and with (right lane) 1000U/mL of IFN-a for 15 min at 37oC.

Scientific Background :STAT2 (Signal transducer and activator of transcription) is a family member of STAT transcription factors that are implicated in programming gene expression in biological events as diverse as embryonic development, programmed cell death, organogenesis, innate immunity, adaptive immunity and cell growth regulation (1). JAKs can phosphorylate and activate STATs. Activation of the JAK/STAT pathway in response to cytokine action can lead to regulation of gene expression during proliferation and differentiation of the immune cells. STATs have been shown to be involved in inflammation, autoimmune and allergic diseases (2).

References :
1. Horvath, C.M.: STAT proteins and transcriptional responses to extracellular signals. Trends Biochem Sci. 2000 Oct;25(10):496-502.

2. Pfitzner, E. et al: The role of STATs in inflammation and inflammatory diseases. Curr Pharm Des. 2004;10(23):2839-50.

Product Sheets (By Lot #) :

B3216-82.pdf

Research Areas :Apoptosis/Autophagy, Cancer, ERK/MAPK Pathway, Inflammation, JAK/STAT Pathway