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Anti-phospho-GABABR2 (Ser783)(G803-465BR)

Anti-phospho-GABABR2 (Ser783)(G803-465BR)

  • $413.00


Description :Rabbit Polyclonal Antibody

Species :

Tag :

Expression System:

Sequence :

Specificity :Recognizes the GABABR2 protein phosphorylated at serine 783

Cited Applications :WB, IF

Cross Reactivity :Human, Mouse, Rat, Bovine, Chicken, Non-Human Primate and Xenopus

Host / Isotype / Clone# :Rabbit, IgG

Immunogen :Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser 783 of GABABR2

Purification :Affinity chromatography

Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Sample Data :Western blot of rat synaptic membrane showing specific immunolabeling of the ~102 k GABABR2 protein phosphorylated at Ser783 (control). The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase: lambda-Ptase). The blot is identical to the control except that it was incubated in lambda Ptase (1200 units for 30 min) before being exposed to the Anti-phospho-GABABR2 (Ser783). The immunolabeling is completely eliminated by treatment with lambda-Ptase.

Scientific Background :Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAB receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. It has recently been demonstrated that AMPK binds directly to GABAB receptors and phosphorylates S783 in the cytoplasmic tail of the R2 subunit and that S783 plays a critical role in enhancing neuronal survival after ischemia as phosphorylation of S783 is evident in many brain regions and is increased dramatically after ischemic injury to the brain.

References :
1. Kuramoto N, Wilkins ME, Fairfax BP, et al, Phospho-dependent functional modulation of GABA(B) receptors by the metabolic sensor AMP-dependent protein kinase. Neuron 53:233-247. 2007.

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Research Areas :Neurobiology