Anti-MYT1L(M92-363R)

Anti-MYT1L(M92-363R)

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Description :Rabbit Polyclonal Antibody

Species :

Tag :

Expression System:

Sequence :

Specificity :Recognizes the MYT1L protein

Cited Applications :WB, ELISA, IF

Cross Reactivity :Human, Mouse and Rat

Host / Isotype / Clone# :Rabbit, IgG

Immunogen :Rabbit polyclonal MYT1L antibody was raised against an 18 amino acid peptide near the carboxy terminus of human MYT1L

Purification :Affinity chromatography

Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Sample Data :Western blot analysis of MYT1L in mouse brain tissue lysate with MYT1L antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.

Scientific Background :MYT1 is a member of a family of neural specific, zinc finger-containing DNA-binding proteins which binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system. MYT1 of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system(1). The recombinant MYT1 fragments containing either the upstream 2 zinc fingers or the downstream 4 zinc fingers bound the same cis regulatory element in the PLP1 promoter in vitro and DNA binding required Zn(2+), but not other divalent cations (2).

References :
1. Kim, J. G. et.al: Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system. J. Neurosci. Res. 50: 272-290, 1997.

2. Kim, J. G. et.al: Novel member of the zinc finger superfamily: a C(2)-HC finger that recognizes a glia-specific gene. Molec. Cell. Biol. 12: 5632-5639, 1992.

Product Sheets (By Lot #) :

O2121-51.pdf

Research Areas :Cancer, Neurobiology, Ser/Thr Kinases, Cancer, Neurobiology, Ser/Thr Kinases