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Description :Rabbit Polyclonal Antibody
Specificity :Recognizes the mTOR protein
Cited Applications :WB, ELISA, ICC
Cross Reactivity :Human and Mouse
Host / Isotype / Clone# :Rabbit, IgG
Immunogen :mTOR antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human mTOR
Purification :Affinity chromatography
Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data :Western blot analysis of mTOR in L1210 cell lysate with mTOR antibody at (A) 1 and (B) 2 ug/mL.
Sample Data :Immunocytochemistry of mTOR in L1210 cells with mTOR antibody at 2 ug/mL.
1. Shamji AF et al: Integration of growth factor and nutrient signaling: implications for cancer biology. Mol. Cell 2003; 12:271-80.
2. Sabatini DM et al: RAFT1: a mammalian protein that binds to FKP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell 1994; 78:35-43.
3. Cardenas ME et al: Molecular mechanisms of immunosuppression by cyclosporine, FK506, and rapamycin. Curr. Opin. Nephrol. Hypertens. 1995; 4:472-7.
4. Fingar DC et al: Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 2004; 23:3151-71.
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Research Areas :AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Metabolic Disorder, Cancer, Inflammation, Metabolic Disorder, Cardiovascular Disease, AKT/PKB Pathway, Apoptosis/Autophagy, Angiogenesis