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Description :Rabbit Polyclonal Antibody
Specificity :Recognizes the LKB1 (STK11) protein
Cited Applications :WB, ELISA
Cross Reactivity :Human and Mouse
Host / Isotype / Clone# :Rabbit, IgG
Immunogen :LKB1 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human LKB1
Purification :Affinity chromatography
Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data :Western blot analysis of LKB1 in PC-3 cell lysate with LKB1 antibody at 1 ug/ml in the (A) absence or (B) presence of blocking peptide.
Scientific Background :LKB1(STK11) is a member of the serine/threonine kinase family which regulates cell polarity and functions as a tumor suppressor. STK11 is a critical barrier to pulmonary tumorigenesis which controlling initiation, differentiation, and metastasis. STK11 plays a central role in restricting HSC entry into cell cycle and in broadly maintaining energy homeostasis in hematopoietic cells through a novel metabolic checkpoint (1). STK11 serves as an essential regulator of HSCs and hematopoiesis, and more generally, points to the critical importance of coupling energy metabolism and stem cell homeostasis (2).
1. Gurumurthy, S. et.al: The Lkb1 metabolic sensor maintains haematopoietic stem cell survival. Nature 468: 659-663, 2010. Note: Erratum: Nature 476: 114 only, 2011.
2. Gan, B.et.al: Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature 468: 701-704, 2010.
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Research Areas :Apoptosis/Autophagy, Cancer, Metabolic Disorder, Ser/Thr Kinases, Cancer, Metabolic Disorder, Apoptosis/Autophagy, Ser/Thr Kinases