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Description :Rabbit Polyclonal Antibody
Specificity :Recognizes the KDM6B protein
Cited Applications :WB, ELISA, ICC, IF
Cross Reactivity :Human, Mouse and Rat
Host / Isotype / Clone# :Rabbit, IgG
Immunogen :KDM6B antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human KDM6B
Purification :Affinity chromatography
Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data :Western blot analysis of KDM6B in K562 cell lysate with KDM6B antibody at 0.5 ug/mL in (A) the absence and (B) the presence of blocking peptide.
Sample Data :Immunocytochemistry of KDM6B in K562 cells with KDM6B antibody at 2.5 ug/mL.
1. Lai F et al: cDNA cloning and genomic structure of three genes localized to human chromosome band 5q31 encoding potential nuclear proteins. Genomics2000; 70:123-30.
2. Agger K et al: UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nature 2007; 449:731-4.
3. De Santa F et al: The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated silencing. Cell 2007; 130:1083-94
4. Sola S et al: p53 interaction with JMJD3 results in its nuclear distribution during mouse neural stem cell differentiation. PLoS One 2011; 6:e18421.
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Research Areas :Cancer, Cell Cycle, Inflammation, Cancer, Inflammation, Cell Cycle