Anti-IRAK2(I10-63BR)

Anti-IRAK2(I10-63BR)

  • $325.00


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Description :Rabbit Polyclonal Antibody

Species :

Tag :

Expression System:

Sequence :

Specificity :Recognizes the IRAK2 protein

Cited Applications :WB, ELISA, ICC, IF

Cross Reactivity :Human and Mouse

Host / Isotype / Clone# :Rabbit, IgG

Immunogen :IRAK2 antibody was raised against a peptide corresponding to 17 amino acids near the carboxy terminus of mouse IRAK2a which is common to all four isoforms

Formulation :PBS + 0.02% sodium azide.

Purification :Affinity chromatography

Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Sample Data :Western blot analysis of IRAK2 in RAW264.7 whole cell lysate with mIRAK2 antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.

Sample Data :Immunocytochemistry of IRAK2 in A-20 cells with IRAK2 antibody at 1 ug/ml.

Scientific Background :Interleukin-1 receptor-associated kinase 2 (IRAK2) is important downstream signaling components of Toll-like receptors (TLRs) (1). IRAKs were first described as signal transducers for IL-1 and later have been implicated in signal transduction of other members of the Toll/IL-1 receptor family. The interleukin-1 receptor (IL-1R) signaling pathway leads to NFkB activation in mammals. To date, four mammalian IRAKs have been identified (IRAK1, IRAK2, IRAK4, and IRAKM) (2). It is believed that IRAK-2 could be an additional therapeutic target for inhibiting IL-1-induced inflammation.

References :
1. Muzio, M. et al: IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science. 1997;278:1612-5.

2. Wesche, H. et al: IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J. Biol. Chem. 1999; 274:19403-10.

Product Sheets (By Lot #) :

O2109-43.pdf

Research Areas :Inflammation, NfkB Pathway, p38 Pathway, Ser/Thr Kinases, Inflammation, p38 Pathway, NfkB Pathway, Ser/Thr Kinases