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Description :Rabbit Polyclonal Antibody
Specificity :Recognizes the human HDAC6 protein
Cited Applications :WB
Cross Reactivity :Weak reaction with human HDAC11 in Western Blot.
HDAC6 from other species may also be detectable.
Immunogen :Synthetic peptide corresponding to c-terminus of human HDAC6 conjugated to KLH.
Formulation :PBS pH 7.4, 50% glycerol
Purification :Affinity Chromatography
Stability :Store at 4°C (add 0.1% NaN3) for several months, and at -20°C for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For optimal performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data :Representative western blot with Anti-HDAC6 (1:1000) using 50ng of human recombinant proteins HDAC1 to HDAC11.
Sample Data :Representative western blot with Anti-HDAC6 (1:1000) using 12ng, 25ng and 50ng of recombinant GST-HDAC6 protein.
Scientific Background :HDAC6 or Histone deacetylase 6 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. The protein encoded by this gene belongs to class II of the histone deacetylase family that regulates important biologic processes beyond histone metabolism and gene transcription (1). HDAC6 is a central component of the stress response that regulates SG formation and potentially contributes to control of RNA metabolism and translation (2).
1. Hubbert, C. et.al: HDAC6 is a microtubule-associated deacetylase. Nature 417: 455-458, 2002.
2. Kwon, S. et.al: The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response. Genes Dev. 21: 3381-3394, 2007.
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Research Areas :Cardiovascular Disease, WNT Signaling, Cardiovascular Disease, WNT Signaling