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Description :Rabbit Polyclonal Antibody
Specificity :Recognizes the DCAMKL2 protein
Cited Applications :WB, ELISA, IHC
Cross Reactivity :Human, Mouse and Rat
Host / Isotype / Clone# :Rabbit, IgG
Immunogen :DCAMKL2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human DCAMKL2.
Formulation :PBS + 0.02% sodium azide.
Purification :Affinity chromatography
Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data :Western blot analysis of DCAMKL2 in rat brain tissue lysate with DCAMKL2 antibody at (A) 1 and (B) 2 ug/ml.
Sample Data :Immunohistochemistry of DCAMKL2 in rat brain tissue with DCAMKL2 antibody at 5 ug/ml.
Scientific Background :DCAMKL2 (also known as doublecortin-like kinase 2 or DCLK2) is a close homologue of doublecortin or DCX which is associated with intractable epilepsy in humans, due to a severe disorganization of the neocortex and hippocampus known as classical lissencephaly. DCX; DCLK2-null mice display frequent spontaneous seizures that originate in the hippocampus, with most animals dying in the first few months of life. DCX and DCLK2 are co-expressed in developing hippocampus, and, in their absence, there is dosage-dependent disrupted hippocampal lamination associated with a cell-autonomous simplification of pyramidal dendritic arborizations leading to reduced inhibitory synaptic tone (1).
1. Kerjan G. Et al: Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures. Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6766-71.
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Research Areas :Cardiovascular Disease, Neurobiology, PKA/PKC Pathway, Ser/Thr Kinases, Neurobiology, Cardiovascular Disease, PKA/PKC Pathway, Ser/Thr Kinases