Anti-Cytokeratin 5 (KRT5)(C91-563R)
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Description :Rabbit Polyclonal Antibody
Specificity :Recognizes the cytokeratin 5 protein
Cited Applications :WB, ELISA
Cross Reactivity :Human
Host / Isotype / Clone# :Rabbit, IgG
Immunogen :Synthetic peptide conjugated to KLH
Formulation :PBS, pH 7.4 with 0.02% sodium azide
Purification :Affinity chromatography
Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data :Western Blot analysis of HeLa cell lysates with Anti-Cytokeratin 5 (KRT5) antibody.
Scientific Background :The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
1. Bertheau,P., Turpin,E., Rickman,D.S et,al Exquisite sensitivity of TP53 mutant and basalbreast cancers to a dose-dense epirubicin-cyclophosphamide regimenPLoS Med. 2007:4 (3), E90.
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Research Areas :Cancer