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Description :Rabbit Polyclonal Antibody
Specificity :Recognizes the 60kDa Cyclin A protein
Cited Applications :ELISA, IP, WB
Ideal working dilutions for each application should be empirically determined by the investigator.
Cross Reactivity :Human, Mouse and Rat
Host Isotype / Clone# :Rabbit, Antiserum
Immunogen :The antibody was produced against a recombinant protein corresponding to the human Cyclin A protein.
Formulation :0.01% (w/v) Sodium Azide
Purification :Delipidation and defribrination
Stability :1yr at –20oC from date of shipment
Sample Data :Immunohistochemical analysis of paraffin-embedded human testes tissue using Anti-Cyclin A antibody.
Scientific Background :Anti-Cyclin A detects cyclin a. Cyclin A is a member of the cyclin family. Cyclin A binds to S phase CDK2 and is required for the cell to progress through the S phase. CDK2/Cyclin A is inhibited by the complex p21CIP. The Anti-Cyclin-A antibody is ideal for investigators involved in cell signaling, cell biology and signal transduction research.
1. Rizzolio F, et al.: Retinoblastoma tumor-suppressor protein phosphorylation and inactivation depend on direct interaction with Pin1. Cell Death and Differentiation 1-10. Nature 2012.
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Research Areas :Cancer, Cell Cycle, Ser/Thr Kinases