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Description :Rabbit Polyclonal Antibody
Specificity :Recognizes the BRSK1protein
Cited Applications :WB, ELISA, IF, IHC
Cross Reactivity :Human, Mouse and Rat
Host / Isotype / Clone# :Rabbit, IgG
Immunogen :BRSK1 antibody was raised against a 28 amino acid synthetic peptide from near the center of human BRSK1
Purification :Affinity chromatography
Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data :Western blot analysis of BRSK1 in human brain tissue lysate with BRSK1 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
Sample Data :Immunohistochemistry of BRSK1 in human brain tissue with BRSK1 antibody at 5 ug/ml.
Scientific Background :BRSK1 is serine/threonine kinases 1 which required for presynaptic differentiation in Caenorhabditis elegans that are needed for neuronal polarization (1). BRSK1 is highly expressed in all specific adult brain regions followed by fetal brain and adult spinal cord. It is also expressed in adult heart, pancreas, testis, ovary, lung, and kidney, and in fetal liver (2).
1. Kishi, M. et.al: Mammalian SAD kinases are required for neuronal polarization. Science 307: 929-932, 2005.
2. Nagase, T.et.al: Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 8: 85-95, 2001.
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Research Areas :Apoptosis/Autophagy, Cancer, Cellular Stress, Metabolic Disorder, Ser/Thr Kinases, Cancer, Metabolic Disorder, Apoptosis/Autophagy, Cellular Stress, Ser/Thr Kinases