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Description :Rabbit Polyclonal Antibody
Specificity :Recognizes the BOK protein. At least three isoforms of BOK are known to exist; this antibody will not detect the smallest isoform. BOK antibody is predicted to not cross-react with other Bcl-2 protein family members.
Cited Applications :ELISA, IHC
Cross Reactivity :Human
Host / Isotype / Clone# :Rabbit, IgG
Immunogen :BOK antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human BOK
Purification :Affinity chromatography
Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data :Immunohistochemistry of BOK in human brain tissue with BOK antibody at 5 ug/mL.
1. Lockshin RA et al: Cell death in the third millennium. Cell Death Differ. 2000; 7:2-7.
2. Cory S, Huang DCS, and Adams JM. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 2003; 22:8590-607.
3. Hsu SY et al: bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Proc. Natl. Acad. Sci. USA 1997; 94:12401-6
4. Soleymanlou N et al: A novel Mtd splice isoform is responsible for trophoblast cell death in pre-eclampsia. Cell Death Differ. 2005; 12:441-52.
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Research Areas :Apoptosis/Autophagy, Cancer, Cancer, Apoptosis/Autophagy