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Description :Rabbit Polyclonal Antibody
Specificity :Recognizes the BMPR2 protein
Cited Applications :WB, ELISA, IHC
Cross Reactivity :Human, Mouse and Rat
Host / Isotype / Clone# :Rabbit, IgG
Immunogen :Recombinant human BMPR2 protein corresponding to amino acids 295-552
Formulation :PBS, pH 7.4 with 0.02% sodium azide
Purification :Affinity chromatography
Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data :Western Blot analysis of Raji cell lysate with Anti-BMPR2.
Sample Data :Immunohistochemical staining of formalin-fixed paraffin-embedded fetal liver showing membrane staining with Anti-BMPR2 at a dilution of 1:100
Scientific Background :BMPR2 is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs that are involved in endochondral bone formation and embryogenesis (1). The loss of interaction and lack of phosphorylation of TCTEL1 by BMPR2 may contribute to the pathogenesis of primary pulmonary hypertension (PPH) and BMPR2 also plays an essential role in human T-cell differentiation (2).
1. Machado, R. D. et.al: Functional interaction between BMPR-II and Tctex-1, a light chain of dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension. Hum. Molec. Genet. 12: 3277-3286, 2003.
2. Cejalvo, T. et.al: Bone morphogenetic protein-2/4 signalling pathway components are expressed in the human thymus and inhibit early T-cell development. Immunology 121: 94-104, 2007.
3. Gangopahyay,A., Oran,M., Bauer,E.M. et al. Bone morphogenetic protein receptor II is a novel mediator of endothelial nitric-oxide synthase activation. J. Biol. Chem. 286 (38), 33134-33140 (2011).
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Research Areas :AKT/PKB Pathway, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, JNK/SAPK Pathway, NfkB Pathway, p38 Pathway, PKA/PKC Pathway, Ser/Thr Kinases, WNT Signaling, Inflammation, AKT/PKB Pathway, ERK/MAPK Pathway, p38 Pathway, JNK/SAPK Pathway, NfkB Pathway, PKA/PKC Pathway, WNT Signaling, Invasion/Metastasis, Ser/Thr Kinases