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Description :Rabbit Polyclonal Antibody
Specificity :Recognizes the BIRC2 protein
Cited Applications :WB, ELISA, IF, IHC
Cross Reactivity :Human and Mouse
Host / Isotype / Clone# :Rabbit, IgG
Immunogen :BIRC2 antibody was raised against a synthetic peptide corresponding to 14 amino acids at the C-terminus of human BIRC2
Purification :Affinity chromatography
Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data :Western blot analysis of BIRC2 in human lung lysate with BIRC2 antibody at 1 (lane A), 2 (lane B), and 4 (lane C) ug/mL, respectively.
Sample Data :Immunohistochemistry of cIAP in human lung cells with BIRC2 antibody at 10 ug/mL.
1. Schimmer AD. Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice. Cancer Res. 2004; 64:7183-90.
2. Rothe M et al: The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell 1995; 83:1243-52.
3. Deveraux QL et al: IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J. 1998; 17:2215-23.
4. Li X et al: TNF-RII and c-IAP1 mediate ubiquitinization and degradation of TRAF 2. Nature 2002; 416:345-7.
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Research Areas :Angiogenesis, Apoptosis/Autophagy, Cancer, Cancer, Apoptosis/Autophagy, Angiogenesis