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Description :Rabbit Polyclonal Antibody
Specificity :Recognizes the AXL protein
Cited Applications :WB, ELISA
Cross Reactivity :Human
Host / Isotype / Clone# :Rabbit, IgG
Immunogen :Peptide at the N-terminal residues of human AXL protein.
Formulation :PBS, pH 7.4 with 0.02% sodium azide
Purification :Affinity chromatography
Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Scientific Background :AXL is a member of the receptor tyrosine kinase family which has oncogenic potential and is implicated in human myeloid leukemia (1). AXL is a member of a complex signaling network that is involved in the control of cell proliferation and differentiation. Overexpression of AXL cDNA in NIH 3T3 cells induces neoplastic transformation of these cells with the concomitant appearance of a 140kDa AXL tyrosine-phosphorylated protein (2). Expression of AXL cDNA in the baculovirus system results in the expression of the appropriate recombinant protein that is recognized by anti-phosphotyrosine antibodies, confirming that the AXL protein is tyrosine phosphorylated.
1. O'Bryan, J.P. et al: Axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. Mol Cell Biol. 1991 Oct;11(10):5016-31.
2. Janssen, J.W. et al:, A novel putative tyrosine kinase receptor with oncogenic potential. Oncogene. 1991 Nov;6(11):2113-20.
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Research Areas :Angiogenesis, Cancer, Receptor Tyrosine Kinases, Cancer, Angiogenesis, Receptor Tyrosine Kinases