FOR BULK ORDER REQUESTS PLEASE CONTACT US
Description :Rabbit Polyclonal Antibody
Specificity :Recognizes the human AC1 protein phosphorylated at Serine 355
Cited Applications :ELISA, IP, WB
Ideal working dilutions for each application should be empirically determined by the investigator.
Cross Reactivity :Human
Host Isotype / Clone# :Rabbit, IgG
Immunogen :The antibody was produced against synthesized peptide corresponding to amino acids 351-359 of Human APC1.
Formulation :0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 + 0.01% (w/v) Sodium Azide
Purification :Immunoaffinity chromatography
Stability :1yr at –20oC from date of shipment
Scientific Background :APC1 (also known as Anaphase promoting complex subunit 1, Cyclosome subunit 1, Protein Tsg24, Mitotic checkpoint regulator and ANAPC1) is 1 of at least 11 subunits of the anaphase-promoting complex (APC), which functions at the metaphase-to-anaphase transition of the cell cycle and is regulated by spindle checkpoint proteins. The APC is an E3 ubiquitin ligase that targets cell cycle regulatory proteins for degradation by the proteasome, thereby allowing progression through the cell cycle.
1. Jorgensen,P.M., et al.: Characterization of the human APC1, the largest subunit of the anaphase-promoting complex. Gene. 2001;262 (1-2): 51-59.
2. Kraft C, et al.: Mitotic regulation of the human anaphase-promoting complex by phosphorylation. Embo J. 2003;22(24):6598-609.
Product Sheets (By Lot #) :
Research Areas :Cancer, Cell Cycle, Neurobiology, p38 Pathway