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Description :Rabbit Polyclonal Antibody
Specificity :Recognizes the APBA protein
Cited Applications :WB
Cross Reactivity :Human, Mouse, Canine, Chicken and non-Human Primate
Host :Rabbit, IgG
Immunogen :Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH
Formulation :100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol.
Purification :Affinity Chromatography
Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data :Western blot of rat hippocampal lysate showing specific immunolabeling of the ~115kDa APBA1 protein.
Scientific Background :APBA1 phosphorylates amyloid precursor protein (APP). There is strong evidence that implicates APP in the pathogenesis of Alzheimer's disease (AD) (1). The phosphorylation of APP at Thr668 might be critical for generating soluble APP (β) and beta-amyloid peptide (aβ) fragments, which are the major components of senile plaques that are found in patient brains inflicted with AD (2,3).
1. Liu, F. et al: Regulation of amyloid precursor protein (APP) phosphorylation and processing by p35/cdk5 and p25/cdk5. FEBS Lett 2003 547:193-196.
2. Ando, K. et al: Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid. J Biol Chem 2001 276:40353-40361.
3. Kamenetz, F. et al: APP processing and synaptic function. Neuron 2003 37:925-937, 2003.
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Research Areas :Neurobiology