ANKK1 (SGK288), Active(A20-10G)

ANKK1 (SGK288), Active(A20-10G)

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Description :Full-length recombinant human ANKK1 (SGK288) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full Length

Genbank Number :NM_178510

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~115 kDa

Gene Aliases :X-kinase, PKK2, SGK288

Formulation :50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Scientific Background :ANKK1 or ankyrin repeat and kinase domain containing 1 is belongs to the Ser/Thr protein kinase family, and protein kinase superfamily that involved in signal transduction pathways (1). ANKK1 is closely linked to DRD2 gene on chr 11, and a well studied restriction fragment length polymorphism (RFLP) designated TaqIA, was originally associated with the DRD2 gene and it was determined to be located in exon 8 of ANKK1 gene where it causes a nonconservative amino acid substitution (2).

References :
1. Manning, G.et.al: The protein kinase complement of the human genome. Science 298: 1912-1934, 2002.

2. Neville, M. J.et.al: Identification and characterization of ANKK1: a novel kinase gene closely linked to DRD2 on chromosome band 11q23.1. Hum. Mutat. 23: 540-545, 2004.

Product Sheets (By Lot #) :

A1423-4.pdf

U1681-6.pdf

Research Areas :Cancer, Neurobiology, Ser/Thr Kinases, Cancer, Neurobiology, Ser/Thr Kinases