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Amlexanox(T02-901)

Amlexanox(T02-901)

  • $325.00


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Description :TBK1 Inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :68302-57-8

Molecular Formula :C16H14N2O4

Appearance :White crystalline powder

Molecular Weight :298.3

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (60 mg/ml). Insoluble in ethanol

Aliases :2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid

Storage and Stability :Store desiccated as supplied at RT for up to 2 years. Store solutions at -20oC for up 3 months.

Scientific Background :Inhibits TANK-binding kinase 1 (TBK1) and IKKε (IC50=1.2 µM)2. Clinically useful in the treatment of aphthus ulcers.

References :
1. L Koch Nat. Rev. Endocrinol. 2013 9:185

2. SM Reilly et al. Nat. Med. 2012 19:313

Molecular Structure :

Product Sheets (By Lot #) :

D3370-4.pdf

Research Areas :Inflammation, NfkB Pathway, Ser/Thr Kinases