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Description :TBK1 Inhibitor
CAS Registry Number :68302-57-8
Molecular Formula :C16H14N2O4
Appearance :White crystalline powder
Molecular Weight :298.3
Purity :>98% (TLC); NMR (Conforms)
Solubilization :May be dissolved in DMSO (60 mg/ml). Insoluble in ethanol
Aliases :2-Amino-7-(1-methylethyl)-5-oxo-5H-benzopyrano[2,3-b]pyridine-3-carboxylic acid
Storage and Stability :Store desiccated as supplied at RT for up to 2 years. Store solutions at -20oC for up 3 months.
Scientific Background :Inhibits TANK-binding kinase 1 (TBK1) and IKKε (IC50=1.2 µM)2. Clinically useful in the treatment of aphthus ulcers.
1. L Koch Nat. Rev. Endocrinol. 2013 9:185
2. SM Reilly et al. Nat. Med. 2012 19:313
Molecular Structure :
Product Sheets (By Lot #) :
Research Areas :Inflammation, NfkB Pathway, Ser/Thr Kinases