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Description :Recombinant human AMHR2 (171-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Genbank Number :NM_020547
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :70 kDa
Gene Aliases :AMHR; MISR2; MISRII; MRII
Scientific Background :AMHR2 is a serine/threonine kinase with a single transmembrane domain belonging to the family of type II receptors for TGF-beta-related proteins which bind the ligand on their own but require the presence of a type I receptor for signal transduction. AMHR2 encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone which results in male sex differentiation and produced in the testes by different cells and has different effects (1). AMHR2 may be a regulator of neuronal pathways which vary in the male population and underlie subtle sex-linked biases (2).
1. Imbeaud, S. et.al: Insensitivity to anti-mullerian hormone due to a mutation in the human anti-mullerian hormone receptor. Nature Genet. 11: 382-388, 1995.
2. Wang, P.-Y. et.al: Mullerian inhibiting substance contributes to sex-linked biases in the brain and behavior. Proc. Nat. Acad. Sci. 106: 7203-7208, 2009.
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Research Areas :Cancer, Ser/Thr Kinases, Cancer, Ser/Thr Kinases