AMHR2 Protein(A38-35G)

AMHR2 Protein(A38-35G)

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Description :Recombinant human AMHR2 (171-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :171-end

Genbank Number :NM_020547

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Western Blot

Molecular Weight :70 kDa

Gene Aliases :AMHR; MISR2; MISRII; MRII

Formulation :50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Scientific Background :AMHR2 is a serine/threonine kinase with a single transmembrane domain belonging to the family of type II receptors for TGF-beta-related proteins which bind the ligand on their own but require the presence of a type I receptor for signal transduction. AMHR2 encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone which results in male sex differentiation and produced in the testes by different cells and has different effects (1). AMHR2 may be a regulator of neuronal pathways which vary in the male population and underlie subtle sex-linked biases (2).

References :
1. Imbeaud, S. et.al: Insensitivity to anti-mullerian hormone due to a mutation in the human anti-mullerian hormone receptor. Nature Genet. 11: 382-388, 1995.

2. Wang, P.-Y. et.al: Mullerian inhibiting substance contributes to sex-linked biases in the brain and behavior. Proc. Nat. Acad. Sci. 106: 7203-7208, 2009.

Product Sheets (By Lot #) :

A1243-3.pdf

Research Areas :Cancer, Ser/Thr Kinases, Cancer, Ser/Thr Kinases