Alsterpaullone(G09-901C)

Alsterpaullone(G09-901C)

  • $65.00


FOR BULK ORDER REQUESTS PLEASE CONTACT US

Description :GSK3beta and CDK5/p25 inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :237430-03-4

Molecular Formula :C16H11N3O3

Appearance :Brown crystalline powder

Molecular Weight :293.3

Purity :>96% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (10 mg/ml)

Aliases :9-Nitro-7,12-dihydroindolo-[3,2-d][1] benzazepin-6(5)-one

Storage and Stability :Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 2 months.

Scientific Background :A potent and selective inhibitor of GSK-3beta and CDK5/p25. Potent inhibitor of CDK1/Cyclin B (IC50=35 nM) (1). Induces apoptosis (2). Inhibits angiogenesis (3).

References :
1. J Bain et al. Biochem. J. 2003 371:199

2. T Lahusen et al. Mol. Carcinog. 2003 36:183

3. S Zahler et al. Angiogenesis 2010 13:239

Molecular Structure :

Product Sheets (By Lot #) :

T2257-42.pdf

Research Areas :Cancer, Neurobiology, Inflammation, Metabolic Disorder, Cardiovascular Disease, AKT/PKB Pathway, NfkB Pathway, WNT Signaling, Apoptosis/Autophagy, Invasion/Metastasis