ALK7 Protein(A08-35G)

ALK7 Protein(A08-35G)

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Description :Recombinant human ALK7 (135-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :135-end

Genbank Number :BC022530

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Western Blot

Molecular Weight :~68 kDa

Gene Aliases :ACVR1C, ACVRLK7

Scientific Background :ALK7 is a type I receptor for the TGFB family of signaling molecules in which type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (1). Alk7 was expressed in all insulin, glucagon, and somatostatin -positive cells of the pancreas (2). GDF3 regulates adipose tissue homeostasis and energy balance under nutrient overload, in part, by signaling through ALK7 and Alk7 showed reduced fat accumulation and partial resistance to diet-induced obesity, similar to Gdf3.

References :
1. Bondestam, J. et.al: cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C). Cytogenet. Cell Genet. 95: 157-162, 2001.

2. Bertolino, P.et.al: Activin B receptor ALK7 is a negative regulator of pancreatic beta-cell function. Proc. Nat. Acad. Sci. 105: 7246-7251, 2008.

Formulation :50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Product Sheets (By Lot #) :

Z1094-2.pdf

B2000-3.pdf

B2084-8.pdf

L2076-9.pdf

L1969-9.pdf

Research Areas :AKT/PKB Pathway, Angiogenesis, Cancer, Cardiovascular Disease, JAK/STAT Pathway, Neurobiology, Ser/Thr Kinases, Cancer, Neurobiology, Cardiovascular Disease, AKT/PKB Pathway, JAK/STAT Pathway, Angiogenesis, Ser/Thr Kinases