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AK-7(S36-904)

AK-7(S36-904)

  • $72.00


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Description :SIRT2 Inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :420831-40-9

Molecular Formula :C19H21BrN2O3S

Appearance :White powder

Melting Point :148-151oC

Molecular Weight :437.4

Purity :98% (TLC)

Solubilization :May be dissolved in DMSO (50 mg/ml); or ethanol (8 mg/ml, warm).

Aliases :N-(3-Bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]benzamide

Storage and Stability :Store desiccated as supplied at ambient temperature for up to 3 years. Store solutions at -20oC for up to 3 months.

Scientific Background :A selective Sirt2 inhibitor (IC50=15.5 μM) which does not inhibit Sirt1 or Sirt31. It down-regulates cholesterol biosynthesis genes in primary striatal neurons1. Displays neuroprotective effects in Huntington’s disease mouse models including improved motor function, extended survival and reduced brain atrophy all of which were associated with reduced aggregated mutant huntingtin2.

References :
1. DM Taylor et al. ACS Chem. Biol. 2011 6:540

2. V Chopra et al. Cell Rep. 2012 2:1492

Molecular Structure :

Product Sheets (By Lot #) :

P3320-3.pdf

Research Areas :Cancer, Cell Cycle, Inflammation