FOR BULK ORDER REQUESTS PLEASE CONTACT US
Description :SIRT2 Inhibitor
CAS Registry Number :420831-40-9
Molecular Formula :C19H21BrN2O3S
Appearance :White powder
Melting Point :148-151oC
Molecular Weight :437.4
Purity :98% (TLC)
Solubilization :May be dissolved in DMSO (50 mg/ml); or ethanol (8 mg/ml, warm).
Storage and Stability :Store desiccated as supplied at ambient temperature for up to 3 years. Store solutions at -20oC for up to 3 months.
Scientific Background :A selective Sirt2 inhibitor (IC50=15.5 μM) which does not inhibit Sirt1 or Sirt31. It down-regulates cholesterol biosynthesis genes in primary striatal neurons1. Displays neuroprotective effects in Huntington’s disease mouse models including improved motor function, extended survival and reduced brain atrophy all of which were associated with reduced aggregated mutant huntingtin2.
1. DM Taylor et al. ACS Chem. Biol. 2011 6:540
2. V Chopra et al. Cell Rep. 2012 2:1492
Molecular Structure :
Product Sheets (By Lot #) :
Research Areas :Cancer, Cell Cycle, Inflammation