AICAR (P47-900B)

AICAR (P47-900B)

  • $155.00


FOR BULK ORDER REQUESTS PLEASE CONTACT US

Description : AMPK Activator

CAS Registry Number: 2627-69-2

Molecular Formula : C9H14N4O5

Appearance : Off white solid

Melting Point : 213-214oC

Molecular Weight : 258.2

Purity : >99% (TLC); NMR (Conforms)

Solubilization : Soluble in DMSO (15 mg/ml); or water (15 mg/ml)

Aliases : 
1. 5-Aminoimidazole-4-carboxamide 1-B-D-ribofuranoside
2. Acadesine

Storage and Stability : Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 3 months.

Scientific Background : Activates AMP-activated protein kinase (AMPK). Promotes ligand-independent activation of the insulin receptor (1). Promotes skeletal muscle autophagy via activation of FoxO3a (2). Controls smooth muscle cell hyperproliferation in vascular disease (3). Cell permeable.

References : 
1. 1. Chopra et al. Diabetologia 2012 55:783
2. AM Sanchez et al. J. Cell Biochem. 2012 113:695
3. N Ferri et al. Vascul. Pharmacol. 2012 56:9

Molecular Structure : Sample Purity Data. For specific information on a given lot, see related technical data sheet. 

Product Sheets (By Lot #):

T2257-24.pdf

Research Areas: Apoptosis/Autophagy, Cancer, Cellular Stress, Metabolic Disorder, Ser/Thr Kinases,