AG-879(N28-909B)

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Description :NGFR inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :148741-30-4

Molecular Formula :C18H24N2OS

Appearance :Yellow powder

Melting Point :223-224o C

Molecular Weight :316.5

Purity :>99% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (25mg/ml) or Ethanol (20 mg/ml)

Aliases :alpha-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide

Storage and Stability :Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 2 months.

Scientific Background :Inhibits NGF receptor tyrosine kinase (TrkA, pp140trk) . Inhibits NGF-induced neurite outgrowth in PC12 cells (1). Displays antitumor activity in a mouse model (2). Blocks the ETK-PAK1 interaction, suppressing RAS-induced PAK1 activation and malignant transformation (3). Cell permeable.

References :
1. M Ohmichi et al. Biochemistry 1993 32:4650

2. M Rende et al. Anticancer Drugs 2006 17:929

3. H He et al. Cancer Biol. Ther. 2004 3:96

Molecular Structure :

Product Sheets (By Lot #) :

T2257-22.pdf

Research Areas :Cancer, Neurobiology, Inflammation, Metabolic Disorder, Cardiovascular Disease, AKT/PKB Pathway, ERK/MAPK Pathway, PKA/PKC Pathway, Apoptosis/Autophagy, Cell Cycle, Angiogenesis, Invasion/Metastasis, Receptor Tyrosine Kinases