AG-490(J02-901)

AG-490(J02-901)

  • $55.00


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Description :JAK2 inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :133550-30-8

Molecular Formula :C17H14N2O3

Appearance :Tan powder

Melting Point :N/A

Molecular Weight :294.3

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (30 mg/ml) or ethanol (10 mg/ml)

Aliases :(E)-2-Cyano-3-(3,4-dihydrophenyl)-N-(phenylmethyl)-2-propenamide

Storage and Stability :Store desiccated as supplied at ambient temperature for up to 1 year. Store solutions at -20oC for up to 1 month.

Scientific Background :A potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently blocked cell growth, induced apoptosis and inhibited DNA synthesis. Blocks the growth of all pre-B ALL cells with no effect on normal B or T cells. Does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src.

References :
1. LH Wang et al. J. Immunol. 1999 162:3897

2. N Meydan et al. Nature 1996 379:645

Molecular Structure :

Product Sheets (By Lot #) :

T2257-23.pdf

Research Areas :Cancer, Inflammation, Cardiovascular Disease, JAK/STAT Pathway, Cytoplasmic Tyrosine Kinases