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Description :JAK2 inhibitor
CAS Registry Number :133550-30-8
Molecular Formula :C17H14N2O3
Appearance :Tan powder
Melting Point :N/A
Molecular Weight :294.3
Purity :>98% (TLC); NMR (Conforms)
Solubilization :May be dissolved in DMSO (30 mg/ml) or ethanol (10 mg/ml)
Storage and Stability :Store desiccated as supplied at ambient temperature for up to 1 year. Store solutions at -20oC for up to 1 month.
Scientific Background :A potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently blocked cell growth, induced apoptosis and inhibited DNA synthesis. Blocks the growth of all pre-B ALL cells with no effect on normal B or T cells. Does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src.
1. LH Wang et al. J. Immunol. 1999 162:3897
2. N Meydan et al. Nature 1996 379:645
Molecular Structure :
Product Sheets (By Lot #) :
Research Areas :Cancer, Inflammation, Cardiovascular Disease, JAK/STAT Pathway, Cytoplasmic Tyrosine Kinases