AG-1517(K11-900B)

AG-1517(K11-900B)

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Description :Tyrosine kinase inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :153436-54-5

Molecular Formula :C16H14BrN3O2 ∙ HCl

Appearance :White to off-white solid

Melting Point :N/A

Molecular Weight :396.7

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (5 mg/ml, warm)

Aliases :
1. 4-(3-Bromoanilino)-6,7-dimethoxyquinazoline hydrochloride

2. PD-153,035

3. SU-5271

4. ZM-252868

Storage and Stability :Store desiccated as supplied at ambient temperature for up to 1 year. Store solutions at -20oC for up to 3 months.

Scientific Background :An ultra-potent inhibitor of epidermal growth factor receptor tyrosine kinase (EGFRK), with an IC50 of 25 pM. Inhibits other tyrosine kinases at micromolar or higher concentrations. It selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression and oncogenic transformation (1). Inhibits the growth of a number of cancer cell lines (2). An extremely useful tool for exploring EGF-mediated cellular signaling (3).

References :
1. DW Fry et al. Science 1994 265:1093

2. M Bos et al. Clin. Cancer Res. 1997 3:2099

3. MP Tetreault et al. J. Cell. Biochem. 2008 105:1240

Molecular Structure :

Product Sheets (By Lot #) :

T2257-40.pdf

Research Areas :Cancer, Metabolic Disorder, Ser/Thr Kinases, Cancer, Metabolic Disorder, Ser/Thr Kinases