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AG-1478(E10-900B)

AG-1478(E10-900B)

  • $121.00


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Description :EGFR inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :175178-82-2

Molecular Formula :C16H14ClN3O2

Appearance :Off white powder

Melting Point :177-178oC

Molecular Weight :315.8

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (30 mg/ml); or Ethanol (10 mg/ml, warm)

Aliases :
1. N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinanine

2. Free Base

Storage and Stability :Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 2 months.

Scientific Background :Potent and selective inhibitor of the EGFR kinase IC50 = 3 nM. Inhibits proliferation of a variety human cancer cell lines (1,2). Reduces pulmonary fibrosis in a rat model (3). Cell permeable.

References :
1. Y Han et al. Cancer. Res.1996 56:3859

2. G Partik et al. J. Cancer Res. Clin. Oncol.1999 125:379

3. AB Rice et al. Am. J. Pathol. 1999 155:213

Molecular Structure :

Product Sheets (By Lot #) :

T2257-50.pdf

Research Areas :Cancer, Inflammation, Metabolic Disorder, Cardiovascular Disease, AKT/PKB Pathway, ERK/MAPK Pathway, PKA/PKC Pathway, Apoptosis/Autophagy, Cell Cycle, Angiogenesis, Invasion/Metastasis, Receptor Tyrosine Kinases