AG-1296(P12-900)

AG-1296(P12-900)

  • $95.00


FOR BULK ORDER REQUESTS PLEASE CONTACT US

Description :PDGFR Inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :146535-11-7

Molecular Formula :C16H14N2O2

Appearance :Off white to yellow powder

Melting Point :N/A

Molecular Weight :266.3

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO

Aliases :6,7-Dimethoxy-3-phenylquinoxaline

Storage and Stability :Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 2 months.

Scientific Background :A potent inhibitor of PDGF receptor tyrosine kinase (PDGFRalpha and beta), IC50=1 µM (1). Also inhibits FGF receptor tyrosine kinase (2), c-kit (3) and FLT3 (4) and reverses transformation induced by activated FLT3 (5). Induces apoptosis in a small-cell lung cancer cell line (H526) (3). Cell permeable.

References :
1. M Kovalenko et al. Biochemistry 1997 36:6260

2. F Strutz et al. Kidney Int. 2001 59:579

3. G W Krystal et al. Cancer Res. 1997 57:2203

4. R Grundler et al. Blood 2003 102:646

5. KF Tse et al. Leukemia 2001 15:1001

Molecular Structure :

Product Sheets (By Lot #) :

T2257-21.pdf

Research Areas :Cancer, AKT/PKB Pathway, ERK/MAPK Pathway, Receptor Tyrosine Kinases