ADCK3 Protein(A37-11G)

ADCK3 Protein(A37-11G)

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Description :Recombinant human ADCK3 (156-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :156-end

Genbank Number :NM_020247

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Western Blot

Molecular Weight :~83 kDa

Gene Aliases :ARCA2; CABC1; COQ10D4; COQ8; SCAR9; COQ8A; ADCK3; CABC1

Formulation :50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Scientific Background :ADCK3 or aarF domain containing kinase 3 is a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. ADCK3 is involved in coenzyme Q10 synthesis which is essential for proper functioning of the mitochondrial respiratory chain (1). Expression of ADCK3 is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis (2).

References :
1. Lagier-Tourenne, C. et.al: ADCK3, an ancestral kinase, is mutated in a form of recessive ataxia associated with coenzyme Q(10) deficiency. Am. J. Hum. Genet. 82: 661-672, 2008.

2. Iiizumi, M. et.al: Isolation of a novel gene, CABC1, encoding a mitochondrial protein that is highly homologous to yeast activity of bc1 complex. Cancer Res. 62: 1246-1250, 2002.

Product Sheets (By Lot #) :

Z1457-3.pdf

P1700-4.pdf

Research Areas :Cancer, Receptor Tyrosine Kinases, Ser/Thr Kinases, Cancer, Ser/Thr Kinases