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Description :Recombinant human ACVR2A (161-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Tag :HIS tag
Expression System:Sf9 insect cells using baculovirus
Genbank Number :NM_001616
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~47 kDa
Gene Aliases :ACTRII; ACVR2
Scientific Background :ACVR2A encodes activin A type II receptor that are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins is an autocrine/paracrine regulator in the human placenta (1). ACVR2A is highly expressed in human brain and ovary (2). Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity.
1. Donaldson, C. J. et.al: Molecular cloning and binding properties of the human type II activin receptor. Biochem. Biophys. Res. Commun. 184: 310-316, 1992.
2. Peng, C. et.al: Expression of the type II activin receptor gene in the human placenta. Endocrinology 133: 3046-3049, 1993.
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Research Areas :Ser/Thr Kinases, Cancer, Cancer, Cytoplasmic Tyrosine Kinases