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AAL-993(F11-900C)

AAL-993(F11-900C)

  • $138.00


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Description :VEGF inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :269390-77-4

Molecular Formula :C20H16F3N3O

Appearance :Light yellow powder

Melting Point :N/A

Molecular Weight :371.1

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (>25 mg/ml); or Ethanol (15 mg/ml)

Aliases :2-((4-Pyridyl)methyl)amino-N-(3 (trifluoromethyl)phenyl)benzamide

Storage and Stability :Store desiccated as supplied at ambient for up to 2 years. Store solutions at -20°C for up to 2 months.

Scientific Background :A potent and selective inhibitor of VEGFR-1 (IC50=130nM), VEGFR-2 (IC50=23nM) and VEGFR-3 (IC50=18nM). At higher concentrations it inhibits PDGFR (640nM), c-Kit (236nM) and CSF-1R (380nM). Inactive at other kinases such as EGFR, FGFR-1, CDK-1, Tie-2, c-Met, IGF-1R, c-Src and c-Abl (1). X-ray crystal studies on AAL-993 complexed to the catalytic domain of diphosphorylated VEGFR- 2 indicates that it binds to an inactive conformation of the protein (2). Cell permeable and active in vivo. Inhibits VEGF-induced angiogenesis (mouse model) (1).

References :
1. R Bhat et al. J. Biol. Chem. 2003 278: 45937

2. SH Ramirez et al. Am. J. Pathol. 2010 176:881

Molecular Structure :

Product Sheets (By Lot #) :

T2257-14.pdf

Research Areas :Cancer, Neurobiology, Cell Cycle, Angiogenesis