A83-01(A09-900)

A83-01(A09-900)

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Description :ALK inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :909910-43-6

Molecular Formula :C25H19N5S

Appearance :Light Yellow powder

Melting Point :N/A

Molecular Weight :421.5

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (20mg/ml)

Aliases :3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide

Storage and Stability :Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 2 months.

Scientific Background :Potent and selective ALK4, 5 and 7 inhibitor (1,2). IC50=45, 12, 7.5 nM respectively. Prevents phosphorylation of Smad2/3 and growth inhibition induced by TGFβ (2). Inhibits differentiation of rat induced pluripotent stem cells and increases clonal expansion efficiency (3). Together with AMI-5 enabled Oct4-induced reprogramming of mouse embryonic fibroblasts (4). Active in rat models. Cell permeable

References :
1. J Vogt et al. Cell Signal. 2011 23:1831

2. M Tojo et al. Cancer Sci. 2012 96:791

3. W Li et al. Cell Stem Cell 2009 4:16

4. X Yuan et al. Stem Cells 2011 29:549

Molecular Structure :

Product Sheets (By Lot #) :

T2257-37.pdf

Research Areas :Cancer, Neurobiology, Cardiovascular Disease, AKT/PKB Pathway, JAK/STAT Pathway, Angiogenesis, Ser/Thr Kinases