ACE2 (19-740) Protein (A51C2-G341F)
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Description :Recombinant human angiotensin-converting enzyme 2 (ACE2) extracellular domain (19-740) was expressed in CHO cells using a C-terminal Fc tag.
Species :Human
Tag :Fc tag
Expression System:CHO cells
Sequence :19-740
Genbank Number :AF291820
Activity :Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight :~150 kDa
Gene Aliases :ACEH
Scientific Background :The angiotensin converting enzyme 2 (ACE2) belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases (1). ACE2 cleaves the angiotensin I and angiotensin II to counterbalancing ACE activity in the regulation of renin angiotensin system (RAS) (1). ACE2 also has the role in regulation of cardiovascular, renal and reproductive systems (1). In addition, ACE2 is a functional receptor for the spike glycoprotein (S) of SARS-CoV, HCoV-NL63 (2), and SARS-CoV-2, which causes the pandemic of the respiratory diseases (COVID-19) around the world in 2020 (3).
References :
1. Imai Y, et al: Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis. Circ J. 2007, 74(3):405-10.
2. Lan J, et al: Crystal structure of the 2019-nCov spike receptor-binding domain bound with the ACE2 receptor. bioRxiv. doi: https://doi.org/10.1101/2020.02.19.956235.
3. Zhou P, et al: A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020, 579:270-89.
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