AXL (R499C), Active(A34-12BG)
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Description :Recombinant human AXL (R499C) (473-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :473-end (R499C)
Genbank Number :NM_021913
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay
Molecular Weight :~76 kDa
Gene Aliases :UFO, JTK11
Scientific Background :AXL, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase which is a member of the TAM (TYRO3/AXL/MER) receptor tyrosine kinase subfamily (1). AXL represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats and Axl transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6 (2). AXL is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding.
References :
1. O'Bryan, J. P.et.al: Axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. Molec. Cell. Biol. 11: 5016-5031, 1991.
2. Varnum, B. C.et.al: Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6. Nature 373: 623-626, 1995.
Product Sheets (By Lot #) :
Research Areas :Angiogenesis, Cancer, Receptor Tyrosine Kinases, Cancer, Angiogenesis, Receptor Tyrosine Kinases