ARAF Protein (A24-35G)
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Description :Recombinant human ARAF (209-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :209-end
Genbank Number :NM_001654
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~70 kDa
Gene Aliases :PKS2, A-RAF, ARAF1, RAFA1
Scientific Background :ARAF belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. ARAF play a critical role in cell growth and development (1).The N-terminal regulatory domain of ARAF interacted with the putative mitochondrial proteins TOM and TIM44. ARAF is expressed predominantly in urogenital tissues (2). The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-raf carrying retrovirus.
References :
1. Huebner, K. et.al: Actively transcribed genes in the raf oncogene group, located on the X chromosome in mouse and human. Proc. Nat. Acad. Sci. 83: 3934-3938, 1986.
2. Lee, J.-E. et.al : The complete sequence and promoter activity of the human A-raf-1 gene (ARAF1). Genomics 20: 43-55, 1994.
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Research Areas :Cancer, Cancer