7-CL-O-Nec-1(R07-901B)

7-CL-O-Nec-1(R07-901B)

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Description :RIPK1 Inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :852391-15-2

Molecular Formula :C13H12ClN3O

Appearance :yellow powder

Molecular Weight :277.71

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved DMSO (25 mg/ml)

Aliases :Nec-1s; 5-((7-Chloro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione

Storage and Stability :Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 3 months.

Scientific Background :A necrostatin-1 analog with superior potency2, selectivity3 and metabolic stability at RIP1 inhibition (IC50 = 206 vs 494 nM)1,2.

References :
1. A Degterev et al. Nat. Chem. Biol. 2005 1:112

2. X Teng et al. Bioorg. Med. Chem. Lett. 2005 15:5039

3. N Takahashi et al. Cell Death Dis. 2012 3:e437

Molecular Structure :

Product Sheets (By Lot #) :

D3370-1.pdf

Research Areas :Inflammation, Cancer, Apoptosis/Autophagy, JAK/STAT Pathway, JNK/SAPK Pathway, p38 Pathway, Ser/Thr Kinases