6BIO(G08-900)

6BIO(G08-900)

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Description :GSK3 inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :667463-62-9

Molecular Formula :C16H10BrN3O2

Appearance :Purple powder

Melting Point :263-265oC

Molecular Weight :356.2

Purity :98% (TLC: 5% CH3OH3 in CH2Cl2, Rf=0.43); NMR (Conforms)

Solubilization :Soluble in DMSO (15 mg/ml); or Ethanol (4 mg/ml, warm)

Aliases :(2'Z,3'E)-6-Bromoindirubin-3'-oxime

Storage and Stability :Store desiccated as supplied at -20°C for up to 1 year. Store solutions at -20°C for up to 2 months.

Scientific Background :Potent and selective inhibitor of glycogen synthase kinase-3 (GSK-3) IC50=5 nM (1). The first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells (2) . Promotes proliferation in mammalian cardiomyocytes (2). A potent inhibitor of malignant lymphoid cell proliferation (3).

References :
1. L Meijer et al. Chem. Biol. 2003 10:1255

2. AS Tseng et al. Chem. Biol. 2006 13:957

3. A Chebel et al. Leuk. Lymphoma 2009 50:2049

Molecular Structure :

Product Sheets (By Lot #) :

T2257-81.pdf

Research Areas :Cancer, Neurobiology, Inflammation, Metabolic Disorder, Cardiovascular Disease, AKT/PKB Pathway, NfkB Pathway, WNT Signaling, Apoptosis/Autophagy, Invasion/Metastasis