5-Azacytidine(D393-904)

5-Azacytidine(D393-904)

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Description :DNA Hypomethylation Agent

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :320-67-2

Molecular Formula :C8H12N4O5

Appearance :White powder

Melting Point :226-232oC (dec.)

Molecular Weight :244.2

Purity :>98% (TLC)

Solubilization :May be dissolved in DMSO (25 mg/ml); or water (12 mg/ml).

Aliases :4-Amino-1-(beta-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one, Ladakamycin

Storage and Stability :Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 1 month.

Scientific Background :Specific inhibitor of DNA methyltransferase. Induces demethylation and reactivation of silenced genes. Increases stem cell reprogramming efficiency. Antitumor agent. Cell permeable.

References :
1. TS Mikkelsen et al. Nature 2008 454:49

2. AM Giraldo et al. Methods Mol. Biol. 2011 791:145

Molecular Structure :

Product Sheets (By Lot #) :

P3320-2.pdf

Research Areas :Apoptosis/Autophagy, Cancer, Cell Cycle, Neurobiology