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Description :DNA Hypomethylation Agent
CAS Registry Number :320-67-2
Molecular Formula :C8H12N4O5
Appearance :White powder
Melting Point :226-232oC (dec.)
Molecular Weight :244.2
Purity :>98% (TLC)
Solubilization :May be dissolved in DMSO (25 mg/ml); or water (12 mg/ml).
Aliases :4-Amino-1-(beta-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one, Ladakamycin
Storage and Stability :Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 1 month.
Scientific Background :Specific inhibitor of DNA methyltransferase. Induces demethylation and reactivation of silenced genes. Increases stem cell reprogramming efficiency. Antitumor agent. Cell permeable.
1. TS Mikkelsen et al. Nature 2008 454:49
2. AM Giraldo et al. Methods Mol. Biol. 2011 791:145
Molecular Structure :
Product Sheets (By Lot #) :
Research Areas :Apoptosis/Autophagy, Cancer, Cell Cycle, Neurobiology