2’-Deoxy-5-fluorocytidine(D353-904D)

2’-Deoxy-5-fluorocytidine(D353-904D)

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Description :Irreversible DNA Methyl Transferase Inhibitor

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CAS Registry Number :10356-76-0

Molecular Formula :C9H12FN3O4

Appearance :White solid

Melting Point :196oC

Molecular Weight :245.2

Purity :>98%

Solubilization :May be dissolved in DMSO (20 mg/ml)

Aliases :5-Fluoro-2’-deoxycytidine; FCDR; FdCyd; NSC-48006

Storage and Stability :Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 1 month.

Scientific Background :A DNA methyltransferase inhibitor currently in clinical trials for breast cancer and other solid tumors1. Like 5’-Azacytidine and decitabine, 2’-Deoxy-5-fluorocytidine is a pyrimidine analog that integrates into chromatin to inhibit DNA methylation2. It blocks proliferation in colon cancer-derived HCT116 cells by activating DNA response pathways3. It inhibits various strains of pathogenic avian influenza viruses in vitro and in vivo4.

References :
1. J Ren et al. Cell Signal. 2011 23:1082

2. H Gowher et al. Cancer Biol. Ther. 2004 3:1062

3. Q Zhao et al. Springerplus 2002 1:65

4. Y Kumaki et al. Antiviral Res. 2011 92:329

Molecular Structure :

Product Sheets (By Lot #) :

P3320-1.pdf

Research Areas :Apoptosis/Autophagy, Cancer, Cell Cycle, Neurobiology