UBE2N (UBC13), Active(U231-380H)
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Description :Recombinant human UBE2N (2-end) was expressed in E. coli cells using an N-terminal His tag.
Species :Human
Tag :His tag
Expression System:E.coli
Sequence :2-end
Genbank Number :NM_003348
Specific Activity :Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Ubiquitin Enzyme Assay, Western Blot
Molecular Weight :18 kDa
Gene Aliases :UBC13; UbcH-ben
Scientific Background :UBE2N (UBC13) or ubiquitin-conjugating enzyme E2N is a member of the E2 ubiquitin-conjugating enzyme family which plays a role in DNA post-replication repair. UBE2N gene encodes a novel human E2 that may be involved in protein degradation in the muscles and testis. UBE2N plays a role in initiation of homologous recombination during double-strand break repair. UBE2N activity may have therapeutic uses in controlling inflammatory responses and it is also important in the induction of immune responses.
References :
1. Mondal, S. et al: A bioluminescent assay for monitoring conjugation of ubiquitin and ubiquitin-like proteins. Anal. Biochem. 510: 41-51, 2016
2. Yamaguchi, T. et al: Cloning and expression of cDNA encoding a human ubiquitin-conjugating enzyme similar to the Drosophila bendless gene product. J. Biochem. 120: 494-497, 1996
3. Zhao, G.Y. et al: A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination. Molec. Cell 25: 663-675, 2007
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Research Areas :Cancer, Cell Cycle, Neurobiology