SOD1 Protein (S26-30G)
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Description : Recombinant full-length human SOD1 was expressed in E. coli cells using an N-terminal GST tag.
Species : Human
Tag : GST tag
Expression System : E.coli
Sequence : Full Length
Genbank Number : NM_000454
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications : Western Blot
Molecular Weight : ~45 kDa
Gene Aliases : Cu/Zn-SOD, ALS, SOD, ALS1, IPOA, Homodimer, Superoxide Dismutase 1
Scientific Background : SOD1 (superoxide dismutase 1) is the major soluble cytoplasmic enzyme responsible for destroying harmful free superoxide radicals in the body thereby providing defence against oxygen free-radical toxicity. Soluble cytoplasmic SOD1 is a copper- and zinc-containing enzyme and the SOD1 gene maps to chromosome 21q22 (1). Mutations in the SOD1 gene have been implicated to be the cause of familial amyotrophic lateral sclerosis, increased age-related muscle mass loss, early development of cataracts, macular degeneration, thymic involution, hepatocellular carcinoma, and shortned lifespan (2).
References :
1. Sherman, L. et al: Nucleotide sequence and expression of human chromosome 21-encoded superoxide dismutase mRNA. Proc. Nat. Acad. Sci. 80: 5465-5469, 1983.
2. Al-Chalabi, Ammar, Recent advances in amyotrophic lateral sclerosis". Current Opinion in Neurology, 2000, 13 (4): 397–405.
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Research Areas : Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cellular Stress, Inflammation, Neurobiology,