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Tau-441 Protein(T08-54N)

Tau-441 Protein(T08-54N)

  • $160.00


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Description :Recombinant full-length human tag-free Tau-441 was expressed in E. coli cells.

Species :Human

Tag :tag-free

Expression System:E.coli

Sequence :Full Length

Genbank Number :P10636-8

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Tau Proteins :Representation of seven Tau proteins, from top to bottom: Tau-441, Tau-410, Tau-412, Tau-381, Tau-383, Tau-352 and Tau-316 (Tau Protein Marker; Cat # T08-07N).

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~64 kDa

Gene Aliases :Tau-F, (N2R4), Tau-4, MAPT, MSTD, PPND, DDPAC, MAPTL, MTBT1, MTBT2, FTDP-17, FLJ31424, MGC138549

Scientific Background :Tau-441 or Tau-F is a member of the Tau family of proteins which function to stabilize the microtubules by binding to them. Tau proteins are subject to phosphorylation and this phenomenon regulates the association of the Tau protein with the microtubules (1). Deposits of Alzheimer's disease AD-associated proteins, such as hyperphosphorylated Tau, as well as other shared misfolded proteins, such as, β-amyloid precursor protein (βAPP), ubiquitin, and various chaperones and protein kinases are thought to play a pathologic role in the cognitive decline and muscular failure. Malfunctioning of Tau proteins is associated with microtubules disintegration and collapsing of the neuronal transport system (2).

References :
1. Zilka, N., et al. Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo. FEBS Lett. 2006; 508: 3582-3588.

2. Rial, A. et al: Calcium Dyshomeostasis in β-Amyloid and Tau-bearing Skeletal Myotubes. J. Biol. Chem., 2004; 279: 3524-53532.

Product Sheets (By Lot #) :

M333-3.pdf

M357-3.pdf

E357-3.pdf

E082-4.pdf

X478-4.pdf

X694-4.pdf

X407-3.pdf

X455-6.pdf

F568-3.pdf

F544-3.pdf

Research Areas :Neurobiology, p38 Pathway, Invasion/Metastasis, Neurobiology, p38 Pathway, Invasion/Metastasis