Tau-441, DYRK1A-phosphorylated & Biotinylated(T08-50RNB)
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Description :Recombinant human tag-free Tau-441 was co-expressed with DYRK1A in E. coli cells, phosphorylated by DYRK1A in vivo and in vitro, then the purified protein was biotinylated prior to the final chromatography purification.
Species :Human
Tag :tag-free
Expression System:E.coli
Sequence :Full length
Genbank Number :P10636-8
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :68~72 kDa
Gene Aliases : Tau-F, (2N4R), Tau-4, MAPT, MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; FLJ31424; MGC138549
Scientific Background :Tau-441 or Tau-F is a member of the Tau family of proteins which function to stabilize the microtubules by binding to them. Tau proteins are subject to phosphorylation and this phenomenon regulates the association of the Tau protein with the microtubules (1). Deposits of Alzheimer's disease AD-associated proteins, such as hyperphosphorylated Tau, as well as other shared misfolded proteins, such as, beta-amyloid precursor protein (betaAPP), ubiquitin, and various chaperones and protein kinases are thought to play a pathologic role in the cognitive decline and muscular failure. Malfunctioning of Tau proteins is associated with microtubules disintegration and collapsing of the neuronal transport system (2).
References :
1. Zilka, N., et al. Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo. FEBS Lett. 2006; 508: 3582-3588.
2. Rial, A. et al: Calcium Dyshomeostasis in -Amyloid and Tau-bearing Skeletal Myotubes. J. Biol. Chem., 2004; 279: 3524-53532.
Product Sheets (By Lot #) :
Research Areas :Invasion/Metastasis, Neurobiology, p38 Pathway