ARPP19 Protein(A76-54G)
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Description :Full-length recombinant human ARPP19 was expressed in E. coli cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:E.coli
Sequence :Full length
Genbank Number :NM_006628
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :46 kDa
Gene Aliases :ARPP-16; ARPP-19; ARPP16; ENSAL
Scientific Background :ARPP19, cAMP-regulated phosphoprotein 19, is specifically phosphorylated at Ser-62 during mitosis by MASTL, also known as the Greatwall kinase. The phos-phorylation of ARPP19 leads to inactivation of PP2A through its interaction with PR55-delta, which is essential in maintaining the activity of CDK1/cyclin B1 and promoting mitotic G2/M transition (1). Significant reduction of ARPP-19 was observed in brains of Alzheimer’s disease and Down syndrome (2). ARPP-19 was also found to contribute to tumor growth in hepatocellular carcinoma and papillary carcinoma (3).
References :
1. Gharbi-Ayachi, A., et al. The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A. Science. 330(6011): 1673-1677, 2010.
2. Kim, S. H., et al. Decreased levels of ARPP-19 and PKA in brains of Down syndrome and Alzheimer's disease. J Neural Transm Suppl. 61: 263-272, 2001.
3. Song, H., et al. Increased ARPP-19 expression is associated with hepatocellular carcinoma. Int J Mol Sci. 16(1): 178-192, 2014.
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Research Areas :Cell Cycle, Cellular Stress