PLCD4 Protein (P442-30DG)
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Description : Recombinant full-length human PLCD4 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species : Human
Tag : GST tag
Expression System : Sf9 insect cells using baculovirus
Sequence : Full Length
Genbank Number : NM_032726
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications : Western Blot
Molecular Weight : 110 kDa
Gene Aliases : EIEE12; PI-PLC; PLC-154; PLC-I; PLC154; PLCD4A; PLCD4B
Scientific Background : 1-phosphatidylinositol 4, 5-bisphosphate phosphodi-esterase delta-4 (PLCD4) is one of the subtypes of phosphoinositide-specific phospholipase C (PI-PLC. Hydrolyzes the phosphatidylinositol 4, 5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1, 4, 5-trisphosphate (IP3). PLCD4 has been implicated to have a key role in cell proliferation. It was found that aberrant expression of PLCD4 may cause oncogenesis in certain tissues through upregulation of ErbB and activation of ERK pathway.
1. Leung DW, et al: Phospholipase C delta-4 overexpression upregulates ErbB1/2 expression, Erk signaling pathway, and proliferation in MCF-7 cells. Mol Cancer. 3:15, 2004.
2. Liu N, et al: A new phospholipase C delta 4 is induced at S-phase of the cell cycle and appears in the nucleus. J Biol Chem. 271(1): 355-60, 1996.
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Research Areas : Cell Cycle, ERK/MAPK Pathway, Metabolic Disorder,