PTPRS (PTP- sigma), Active(P64-21G)
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Description :Recombinant human PTPRS (883-1210) was expressed in E.coli cells using a N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:E.coli
Sequence :883-1210
Genbank Number :NM_130855
Specific Activity :Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet. 
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Phosphatase Assay, Western Blot
Molecular Weight :~63 kDa
Gene Aliases :PTP-sigma
Scientific Background :PTPRS is a member of a subfamily of receptor type PTPases that is characterized by the presence of an extracellular cell adhesion molecule-like motif and 2 intracellular phosphatase domains (1). The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis (2).
References :
1. Wagner, J. et al: Olsen, A. S.: Physical mapping of receptor type protein tyrosine phosphatase sigma (PTPRS) to human chromosome 19p13.3. Genomics 38: 76-78, 1996.
2. Elchebly, M. et al: Neuroendocrine dysplasia in mice lacking protein tyrosine phosphatase sigma. Nature Genet. 21: 330-333, 1999.
Product Sheets (By Lot #) :
Research Areas :Cancer, Cardiovascular Disease, Phosphatases, Cancer, Cardiovascular Disease, Phosphatases